Isaiah 49:16 is one of the most beautiful scriptures we have from Isaiah, “Behold, I have graven thee upon the palms of my hands; thy walls are continually before me.” But is there deeper meaning in both parts of this verse that we don’t usually see? Let’s look at the first sentence, “I have graven thee upon the palms of my hands.” Just five chapters earlier Isaiah wrote to post-captivity Israel. He first comforted them about Jesus’ loyalty to them, and then remarked in verse five a way that the Israelites could show their loyalty to Jesus, “. . .another shall subscribe with his hand unto the Lord, and surname himself by the name of Israel.” The word “subscribe” comes from the Hebrew ​​כָּתַב (pronounced ​​kāṯaḇ) which can be translated as write, inscribe, or engrave. Thus covenant Israel is invited to “inscribe” Christ on their hands to show that they made a covenant with Him and will never forget Him (how can you when you use your hands for everything you do?!). So Christ “engraving” us on His hands is a physical act through His crucifixion, but also symbolic that in everything He does He will not forget us. (Source)